God I hope this isn't another Punisher kills the MU. 616 Punisher hasn't killed any villain of note and is now going to take out Earth's Mightiest Heroes? With guns?
#13 of the Punisher has Frank steal an unidentified piece of technology from an illegal auction which use to belong to Doc Ock and recent interviews have suggested that Frank will acquire something which will level the playing field a little between him and the super-powered community.
All of that said, Marvel are hardly going to let a creator allow Frank to kill off high profile Avengers, so whilst I'm optimistic about the new series and it seems to be getting the kind of publicity that the Punisher has lacked for years it seems the case that the character will face the same restrictions as before - namely that he will never be allowed to kill off anyone of note.