Previous Post She-Hulk went crazy in an issue in 2003, and laid waste to a town, with Hawkeye trying to defeat her (while admiring his own moves, nonstop). If no one was killed, it was no thanks to Jennifer.

... she has a tendency for having a rather wild lifestyle. In Dan Slott's series, it was established that her parties occassionally caused structural damage to the Mansion

Of course, it's not the same as being mad, but it may be indicative of some psychological issues...