The Initiative: a new class. Kind of surprised that this isn't an Invasion crossover. This makes me happy. I recognize Annex and Prodigy, not sure about the rest. Butterball seems like one of those characters that will polarize fans quickly.
Classic Avengers: no surprise it is getting canned. I'm sorry, but most of those early tales are far from "Classic". They should have done a few then jumped ahead to Thomas/Buscema.
Iron Fist: It seems like I was in the minority of fans who really liked the last stand-alone issue spotlighting an Iron Fist of the past. I'm looking forward to the next.
Giant-Size Hulk: I've dropped Hulk, but at last Roger Stern is writing for Marvel again. I will pick this up for his tale.
X-Factor special spotlighting Quicksilver: double yay!
It doesn't surprise me that there are tie-in mini's to Invasion. I might pick up the FF-the team of Sacasa and Kitson sounds promising.
..the Man-Beast is handled in the Wolverine title featuring the High Evolutionary. Actually, I would think Wolverine and the MB would make a solid set of antagonists---and the MB has such a long and interesting history.