Maybe it should turn out that some of Scourge's victims were actually Skrulls, who ended up getting killed off because they didn't take into account someone would be offing super-villains. The Vamp, the Melter, Basilisk and several others could have been Skrulls. Of course, we would need a writer to use the surviving villains in interesting ways so people would like them again. I always thought, and still think, that Brubaker could do wonders with the Vamp, making her a big espionage-style character working for guys like Hydra, AIM, and whatnot.
I've been kicking around some Super-Villan Team Up ideas just to amuse myself, and one of those involved a lesser-used mystic villain (someone like the Left Hand or Tai from New Warriors) rescuing some villains from various hells. These villains discover their abilities have been altered somewhat (and increased in all cases) by their time in hell. Characters like Melter find that their power has been made a part of them.
However, what they discover through trial and error, is that every time they use their hell-born power, it's like a beacon announcing their whereabouts to the hell-lord whose domain they escaped from.
I had thought about using Melter and Catseye, but hadn't gone much further than that.