..Killgrave the Purple Man is now a character who can only be used in certain circumstances after Alias established him as a mind-controller who gets off on sexually humiliating female superheroes. There have been one or two Marvel head-grabbers who've gone part of the way down that route before (e.g. Mesmero) but not as far. Now whenever he appears in a book with a female hero the writer has to explain why she's still wearing clothes and not sitting on his lap.
Perhaps change this by having his powers transferred to a woman?
...doesnt mean he always must. Simply because hes done it before doesnt mean he will,should or must constantly do the same thing. Thats like saying Norman Osborn has to throw every blonde he meets off a bridge.