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Excellent questions! Looking forward to see if anyone can offer insight and/or connections to many of these seemingly disconnected backstories. It would be nice to more straightforward canon attached to them so as to return them their awe-inspiring presence and not be just an interchangable crew of giants that a handful of Earth superhumans can knock over every time.
And now we got some new backstory happening in the Origin of Tony Stark where it's revealed a previously unrevealed race of Aspirants were evidentally their equals if not for their internal bickering. All summarized in this spoiler review for IM #13 here:
http://www.comicboards.com/php/show.php?msg=ironman-2013071717312029

I miss Dad and Dan.
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Meanwhile in A+X
#10...
http://www.comicbookresources.com/?page=preview&id=17272
http://forums.comicbookresources.com/showthread.php?460240-Seems-Domino-has-no-hatred-against-Wanda-A-X-10-preview
...nevermind, best not even acknowledge any of this as a probable 616 adventure. [Are Celestial Extermination Drones even an established concept??]
I miss Dad and Dan.