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Quote: Courtesy of USA Weekend, which reveals not only who Peter's new girlfriend will be (which really doesn't come as much of a surprise) but also his new career (which should remind folks of something from the Howard Mackie reboot era):
Quote: http://whosnews.usaweekend.com/2010/10/first-look-trailer-at-the-upcoming-spider-man-big-time-comics/
Remember Dan Slott said, when talking about Mutant Zero from Avengers: The Initative, that it'd be a character so big that even non-comic book fans would recognize her. The only real character who fit that description who wasn't being used at the time was Jean Gray.
It turned out to be Typhoid Mary.
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Typoid Mary was in the then-recent Elektra movie, so technically she would be known by people who don't follow comics.