Out of the choices you provided I think the one that looks to be most viable is with Doc Ock:
1. Altered Peter - could be but does not explain the personality and has been done before.
2. Morbius bite - Potential but still Peter and not what has been advertised.
3. Spider-man 2099 - out of left field as 2099 not been a paret of any stopry line (and Miguel is good i thought).
4. Ock mind switch - Ending to a looong sotryline. Makes sense.
5. Phil Ulrich or Kingsley - think there are other plans for these 2.
6. jackal new clone - please no.
I would remind that all statements about the allegedly Superior Spidey not being Peter could be lies (after all Marvel does lie), or perhaps half true.
Morbius bite could alter Peter in terms of powers and perhaps also alters his personality a bit.
Or they could fall back on the old trope "It's magic, we don't have to explain it."