Correct. Little to no doubt about that
I read an IGN article that said Peter will be left depressed and living with the consequences of his failures as Spider-Man. That indicates very strongly to me that he loses someone..I don't think it's Mary Jane, I think it'll be Aunt May at last, tying up the plot threads of One More Day as Spencer has been promising that.
I think they have basically exhausted Aunt May as a character. Plus if the deal is rescinded then it would lead to her death.